Tg(Th-MYCN)41Waw
Transgene Detail

Summary

• Symbol: Tg(Th-MYCN)41Waw
• Name: transgene insertion 41, William A Weiss
• MGI ID: MGI:3039395
• Synonyms: MYCN, Th-MYCN, TH-NMYC
• Transgene: Tg(Th-MYCN)41Waw Location: unknown
• Alliance: Tg(Th-MYCN)41Waw page

Histology and immunohistochemistry of neuroblastoma Tg(Th-MYCN)41Waw/0 tumors

Show the 4 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: BALB/c and C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Th-MYCN)41Waw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYCN (4613)

  Mycn	(MGI:97357)
  Mycs	(MGI:1332242)

• Tg(Th-MYCN)41Waw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Th (25085)

  Th	(MGI:98735)

• Mutation details: The rat tyrosine hydrolase promoter directs expression of human v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN) to migrating cells of the neural crest during early development. Expression was found in the adrenal gland with marginal expression in brain, heart, testes and spleen. (J:41126)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Th-MYCN)41Waw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Mice carrying this transgene on a 129X1/SvJ background are predisposed to neuroblastoma and show many of the features of the human childhood disease. Genomic analysis of tumors from these mice have shown allelic imbalance in chromosomal regions orthologous to those found in human neuroblastoma.

References

• Original: J:41126 Weiss WA, et al., Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J. 1997 Jun 2;16(11):2985-95
• All: 74 reference(s)