Cul7^tm1Jdec
Targeted Allele Detail

Summary

• Symbol: Cul7^tm1Jdec
• Name: cullin 7; targeted mutation 1, James A DeCaprio
• MGI ID: MGI:3039533
• Synonyms: p185^-
• Gene: Cul7 Location: Chr17:46961264-46975290 bp, + strand Genetic Position: Chr17, 22.9 cM
• Alliance: Cul7^tm1Jdec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85161
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a FRT site flanked NEO cassette and a loxP site was utilized in the construction of this mutant. This selection cassette was inserted upstream of exon 2 of the targeted gene, and another loxP site was inserted downstream of exon 4. Mice carrying this allele, Cul7^tm2.1, were crossed to mice expressing FLP recombinase to remove the FRT site flanked neo selection cassette. Subsequent cre excision removed exons 2 through 4 leaving a single loxP site. (J:85161)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul7 Mutation: 72 strains or lines available

References

• Original: J:85161 Arai T, et al., Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9855-60
• All: 4 reference(s)