Hr^rh-bmh
Spontaneous Allele Detail

Summary

• Symbol: Hr^rh-bmh
• Name: lysine demethylase and nuclear receptor corepressor; rhino-bald Mill Hill
• MGI ID: MGI:3039558
• Synonyms: hr^rhbmh
• Gene: Hr Location: Chr14:70789652-70810988 bp, + strand Genetic Position: Chr14, 36.32 cM
• Alliance: Hr^rh-bmh page

Mutation origin

• Strain of Origin: C57BL/6JRj x CBA/JRj

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: The mutation in the bald Mill Hill mouse was determined to be a small 296 bp deletion of genomic DNA that includes part of exon 19 and the 3' UTR of the gene. The mutant allele is expressed in a similar pattern to the wild-type message. However the resulting protein is 150 rather than 130 kDa in size. (J:89321)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hr Mutation: 87 strains or lines available

References

• Original: J:89321 Brancaz MV, et al., A new allele of the mouse hairless gene interferes with Hox/LacZ transgene regulation in hair follicle primordia. Exp Mol Pathol. 2004 Apr;76(2):173-81
• All: 3 reference(s)