Card11^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Card11^tm1Litt
• Name: caspase recruitment domain family, member 11; targeted mutation 1, Dan R Littman
• MGI ID: MGI:3039682
• Synonyms: CARMA1^-, carma1^FN
• Gene: Card11 Location: Chr5:140858745-140986337 bp, - strand Genetic Position: Chr5, 79.42 cM
• Alliance: Card11^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89322
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted into intron 2 and a loxP-flanked neomycin selection cassette was inserted into intron 4 through homologous recombination. Western blot analysis on extracts derived from splenocytes of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:89322)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Card11 Mutation: 59 strains or lines available

References

• Original: J:89322 Egawa T, et al., Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol. 2003 Jul 15;13(14):1252-8
• All: 11 reference(s)