Tg(tetO-MYC)36aBop
Transgene Detail

Summary

• Symbol: Tg(tetO-MYC)36aBop
• Name: transgene insertion 36a, J Michael Bishop
• MGI ID: MGI:3039697
• Synonyms: TetO-c-Myc, Teto-MYC, Tg(tetO-MYC)36Bop, TRE-MYC
• Transgene: Tg(tetO-MYC)36aBop Location: unknown
• Alliance: Tg(tetO-MYC)36aBop page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-MYC)36aBop expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: This transgene contains a human v-myc avian myelocytomatosis viral oncogene homolog cDNA and regulatory elements from the bacterial tetracycline-resistance operon. There are two founder #36 lines. Transgene insertions are on an autosomal chromosome in this line. (J:59444)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO-MYC)36aBop

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Renal Cell Carcinoma J:222943.

References

• Original: J:59444 Felsher DW, et al., Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell. 1999 Aug;4(2):199-207
• All: 67 reference(s)