Tg(Mt1-RET)304Ina
Transgene Detail

Summary

• Symbol: Tg(Mt1-RET)304Ina
• Name: transgene insertion 304, Izumi Nakashima
• MGI ID: MGI:3039777
• Synonyms: MT-ret
• Transgene: Tg(Mt1-RET)304Ina Location: unknown
• Alliance: Tg(Mt1-RET)304Ina page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6) X BALB/c

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-RET)304Ina expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RET (5979)

  Ret	(MGI:97902)

• Mutation details: Human RET proto-oncogene cDNA driven by the mouse metallothionein 1 promoter/enhancer. This mouse is predicted to have 5 copies of the transgene. Northern blot analysis revealed high levels of transgene expression in tumors and varying levels in melanin-producing cells of other tissues in mice of this line, including skin, muscle and Harderian glands. (J:70622)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Mt1-RET)304Ina

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Founder only. Lines 304a, 304b, and 304c were derived from this mouse. Additional founder numbers: 108, 192, 207, 242, 301, 319.

References

• Original: J:70622 Iwamoto T, et al., Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J. 1991 Nov;10(11):3167-75
• All: 40 reference(s)