Ctnnb1^{tm1(Nfkbia)Rsu}
Targeted Allele Detail

Summary

• Symbol: Ctnnb1^{tm1(Nfkbia)Rsu}
• Name: catenin beta 1; targeted mutation 1, Ruth Schmidt-Ullrich
• MGI ID: MGI:3039783
• Synonyms: c^{IkappaBalphadeltaN}
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^{tm1(Nfkbia)Rsu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71744
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Ctnnb1^{tm1(Nfkbia)Rsu} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NFKBIA (4792)

  Nfkbia

  (MGI:104741)

• Mutation details: An Nfkbia cDNA fragment encoding amino acids 71 through 317 of Nfkbia was inserted at start codon of the endogenous gene. The coding region of the first coding exon and the following 4 downstream exons were replaced by the inserted sequences. The encoded mutant Nfkbia protein was expressed in most tissues, lacked the N-terminal destruction box degradation signal, and has been previously shown to inhibit Nfkb1. (J:71744)

Disease models

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

References

• Original: J:71744 Schmidt-Ullrich R, et al., Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development. 2001 Oct;128(19):3843-53
• All: 8 reference(s)