Itpkb^T-less
Chemically induced Allele Detail

Summary

• Symbol: Itpkb^T-less
• Name: inositol 1,4,5-trisphosphate 3-kinase B; Ms. T-less
• MGI ID: MGI:3039799
• Synonyms: Itpkb^-, Ms T less
• Gene: Itpkb Location: Chr1:180158050-180252367 bp, + strand Genetic Position: Chr1, 84.27 cM, cytoband H5
• Alliance: Itpkb^T-less page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to A transversion at position 596 of the transcript created a premature stop codon in place of cysteine 199. Northern blot revealed abundant transcript in mutant DP thymocytes, putatively encoding an N-terminally truncated protein lacking the targeting, regulating, and catalytic domains. Western blot detected no full-length protein. Kinase activity was about 50% less than that in wild-type thymocytes. (J:89286)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itpkb Mutation: 40 strains or lines available

References

• Original: J:89286 Wen BG, et al., Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5604-9
• All: 4 reference(s)