Prm2^tm1Eddy
Targeted Allele Detail

Summary

• Symbol: Prm2^tm1Eddy
• Name: protamine 2; targeted mutation 1, Edward M Eddy
• MGI ID: MGI:3039800
• Gene: Prm2 Location: Chr16:10609241-10609969 bp, - strand Genetic Position: Chr16, 5.84 cM
• Alliance: Prm2^tm1Eddy page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:69127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced 66 bp in exon 1 via homologous recombination. Analysis of 129 derived sperm from chimeras showed reduced PRM1 and PRM2 protein expression. (J:69127)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prm2 Mutation: 8 strains or lines available

Notes

ES cell line was either R1 or BK4. Haploinsufficiency of Prm2 prevents genetic transmission of the mutated allele and generation of non-chimeric heterozygous mice. All phenotype data reported are from chimeric mice.

References

• Original: J:69127 Cho C, et al., Haploinsufficiency of protamine-1 or -2 causes infertility in mice. Nat Genet. 2001 May;28(1):82-6
• All: 2 reference(s)