Ntrk2^tm1Rohr
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm1Rohr
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1, Baerbel Rohrer
• MGI ID: MGI:3039928
• Synonyms: trkB^-, trkB^neo
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm1Rohr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89227
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon, exon S, was replaced with a neo cassette by homologous recombination. Exon S, which encodes 31 codons for the signal peptide and the start codon, is common to both kinase and nonkinase isoforms. While Northern blot of homozygous mutants showed a small amount of aberrant transcript, Western blotting demonstrated that no receptors were detected in the homozygous mutant mice brains. (J:88782)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:89227 Rohrer B, et al., Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina. J Neurosci. 1999 Oct 15;19(20):8919-30
• All: 15 reference(s)