Mapk7^tm1.1Jdl
Targeted Allele Detail

Summary

• Symbol: Mapk7^tm1.1Jdl
• Name: mitogen-activated protein kinase 7; targeted mutation 1.1, Jiing-Dwan Lee
• MGI ID: MGI:3040181
• Synonyms: BMK1-CKO
• Gene: Mapk7 Location: Chr11:61379638-61385101 bp, - strand Genetic Position: Chr11, 37.96 cM
• Alliance: Mapk7^tm1.1Jdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89215
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Floxed exons 4-7 in Mapk7^tm1Jdl were removed by Cre-mediated recombination, leaving a single loxP site. These exons encode for the kinase domain and the unique C-terminal nonkinase region of the protein. Western blot of homozygous mutant livers confirmed absence of protein. (J:89215)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk7 Mutation: 32 strains or lines available

References

• Original: J:89215 Hayashi M, et al., Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest. 2004 Apr;113(8):1138-48
• All: 1 reference(s)