Cocia5^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Cocia5^C57BL/6J
• Name: cocaine induced activation 5; C57BL/6J
• MGI ID: MGI:3040218
• QTL: Cocia5 Location: unknown Genetic Position: Chr1, cM position of peak correlated region/allele: 43.94 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased cocaine induced activation of locomotor activity compared to A/J. (J:88790)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:88790

Linkage analysis was performed on 15 AcB and 21 BcA (A=A/J; B=C57BL/6J) recombinant congenic strains to identify QTLs associated with cocaine-induced activation of locomotor activity. A panel of 625 markers at an average spacing of 2.6 cM was used in thescreen. Parental strain C57BL/6J exhibits increased cocaine-induced activation of locomotor activity compared to parental strain A/J. Loci with significance threshold of P<0.00001 are reported.

Two loci were identified on mouse Chromosome 1, Cocia4 (cocaine induced activation 4) and Cocia5. Cocia4 mapped to 15 cM near D1Mit211. The QTL range of Cocia4 spans from 13 cM - 25.7 cM. C57BL/6J-derived alleles confer decreased cocaine-induced locomotor activation at Cocia4. Cocia5 mapped to 52 cM near D1Mit415. The QTL range of Cocia5 spans from 36.9 cM - 58.5 cM. C57BL/6J-derived alleles confer increased cocaine-induced locomotor activation at Cocia5. Candidate genes mapping near Cocia5 are Chrnd and Chrng. Cocia5 colocalizes with a previously identified cocaine related behavior QTL, Cocrb1 (52.3 cM).

Two loci were identified on mouse Chromosome 5, Cocia6 and Cocia7. Cocia6 mapped to 24 cM near D5Mit182. The QTL range of Cocia6 spans from 1 cM - 28 cM. A/J-derived alleles confer increased cocaine-induced locomotor activation at Cocia6. Candidate genes mapping hear Cocia6 are Htr5a and Drd5. Cocia6 colocalizes with a previously identified dopamine receptor binding QTL, Drb1 (7 cM). Cocia7 mapped to 84 cM near D5Mit409. The QTL range of Cocia7 spans from 84 cM - 86 cM. C57BL/6J-derived alleles confer increased cocaine-induced locomotor activation at Cocia7.

Cocia8 mapped to 7 cM on mouse Chromosome 6 near D6Mit159. The QTL range of Cocia8 spans 7 cM - 26.4 cM. C57BL/6J-derived alleles confer increased cocaine-induced locomotor activation at Cocia8. A previously identified cocaine-related behavior QTL, Cocrb7 (26 cM), maps near Cocia8.

Cocia9 mapped to 26.5 cM on mouse Chromosome 7 near D7Mit83. The QTL range of Cocia9 spans 9.4 cM - 27.8 cM. C57BL/6J-derived alleles confer increased cocaine-induced locomotor activation at Cocia9. A candidate gene mapping near Cocia9 is Tph1.

Cocia10 mapped to 23 cM on mouse Chromosome 9 near D9Mit328. The QTL range of Cocia10 spans 9 cM - 28 cM. C57BL/6J-derived alleles confer increased cocaine-induced locomotor activation at Cocia10. Candidate genes mapping near Cocia10 are Grik4 and Drd2. Cocia10 colocializes with a previously identified cocaine related behavior QTL, Cocrb8 (29 cM).

Cocia11 mapped to 35 cM on mouse Chromosome 13 near D13Mit54. The QTL range of Cocia11 spans 21 cM - 37 cM. C57BL/6J-derived alleles confer increased cocaine-induced locomotor activation at Cocia11. A candidate gene mapping near Cocia11 is Drd1a.

Cocia12 mapped to 52.5 cM on mouse Chromosome 16 near D16Mit188. The QTL range of Cocia12 spans 36 cM - 66 cM. C57BL/6J-derived alleles confer increased cocaine-induced locomotor activation at Cocia12. A candidate gene mapping near Cocia12 is Grik1. Cocia12 colocalizes with a previously identifieddopamine receptor binding QTL, Drb9 (59 cM).

Cocia13 mapped to 24.5 cM on mouse Chromosome 17 near D17Mit66. The QTL range of Cocia13 spans 22.5 cM - 24.5 cM. A/J-derived alleles confer confer increased cocaine-induced locomotor activation at Cocia13.

Cocia14 mapped to 45 cM on mouse Chromosome 18 near D18Mit186. The QTL range of Cocia14 spans 45 cM - 48 cM.

References

• Original: J:88790 Gill KJ, et al., Confirmation of quantitative trait loci for cocaine-induced activation in the AcB/BcA series of recombinant congenic strains. Pharmacogenetics. 2003 Jun;13(6):329-38
• All: 1 reference(s)