Tg(TagRb)1Plm
Transgene Detail

Summary

• Symbol: Tg(TagRb)1Plm
• Name: transgene insertion 1, Pamela L Mellon
• MGI ID: MGI:3040285
• Synonyms: hLHBeta-Tag, hLHB-Tag, LHbeta-Tag, LHBETATAG, LHB-Tag, TAg-RB
• Transgene: Tg(TagRb)1Plm Location: unknown
• Alliance: Tg(TagRb)1Plm page

Transgene origin

• Strain of Origin: (C57BL/6J x BALB/cJ)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains the human luteinizing hormone beta promoter and the wild-type alleles of the SV40 Tag and tag (large and small T antigen) genes. (J:10320)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(TagRb)1Plm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Fifteen lines were produced. In this line mice developed bilateral ocular neoplasms at about five months of age. Retinal tumors were first observed at about 2 months, and filled the vitreous cavity by 5-6 months of age.

References

• Original: J:10320 Windle JJ, et al., Retinoblastoma in transgenic mice. Nature. 1990 Feb 15;343(6259):665-9
• All: 28 reference(s)