L1cam^tm1.1Vlem
Targeted Allele Detail

Summary

• Symbol: L1cam^tm1.1Vlem
• Name: L1 cell adhesion molecule; targeted mutation 1.1 Vance Lemmon
• MGI ID: MGI:3040294
• Synonyms: L1-6D, L1cam^{tm1.1(L1-6D)Lem}
• Gene: L1cam Location: ChrX:72897384-72924843 bp, - strand Genetic Position: ChrX, 37.43 cM, cytoband A6-B
• Alliance: L1cam^tm1.1Vlem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89300
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed floxed exons 12 and 14 of L1cam^tm1Vlem, leaving a neo cassette in intron 14. These exons encode the sixth Ig domain. Protein expression levels were similar in mutant and wild-type lymphocytes, as demonstrated by Western blot, and flow cytometry confirmed the loss of expression of the sixth Ig domain epitope. (J:89300)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any L1cam Mutation: 12 strains or lines available

References

• Original: J:89300 Itoh K, et al., Brain development in mice lacking L1-L1 homophilic adhesion. J Cell Biol. 2004 Apr12;165(1):145-54
• All: 4 reference(s)