Tg(Mt1-Tgfa)147Bri
Transgene Detail

Summary

• Symbol: Tg(Mt1-Tgfa)147Bri
• Name: transgene insertion 147, Ralph L Brinster
• MGI ID: MGI:3040323
• Synonyms: 1687-8, 1687-8 line of MT-TGFalpha, MT-TGFalpha-hGH Line 1687-8, Tg(Mt-1,rTgfa)Bri147, TgN(Mt1Tgfa)147Bri
• Transgene: Tg(Mt1-Tgfa)147Bri Location: unknown
• Alliance: Tg(Mt1-Tgfa)147Bri page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-Tgfa)147Bri expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Tgfa (24827)

  Tgfa	(MGI:98724)

• Mutation details: The transgene contains the mouse metallothionein 1 promoter and rat transforming growth factor alpha cDNA. The vector also contains part of the human growth hormone gene (containing poly(A)). (J:28451)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Mt1-Tgfa)147Bri

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Mice on a mixed C57BL/6 x SJL background that carry this transgene are also called "MT-TGFalpha-hGH Line 1687-8."

Line 148 ("MT-TGFalpha-hGH Line 1694-2") also carries this transgene.

References

• Original: J:28451 Sandgren EP, et al., Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell. 1990 Jun 15;61(6):1121-35
• All: 5 reference(s)