Pnpla6^tm1Mvc
Targeted Allele Detail

Summary

• Symbol: Pnpla6^tm1Mvc
• Name: patatin-like phospholipase domain containing 6; targeted mutation 1, Moses V Chao
• MGI ID: MGI:3040330
• Synonyms: Nte^fl, NTEfl, Nte^flox
• Gene: Pnpla6 Location: Chr8:3565384-3594267 bp, + strand Genetic Position: Chr8, 1.92 cM
• Alliance: Pnpla6^tm1Mvc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Floxed exons 2-5 remained following the excision of a floxed neomycin resistance gene in the 5' UTR by transient Cre expression. Western blot analysis of homozygous mutant brains indicated protein was present at wild-type levels. (J:89288)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnpla6 Mutation: 63 strains or lines available

References

• Original: J:89288 Akassoglou K, et al., Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5075-80
• All: 4 reference(s)