Tg(MMTVTGFB1)46Hlm
Transgene Detail

Summary

• Symbol: Tg(MMTVTGFB1)46Hlm
• Name: transgene insertion 46, Harold L Moses
• MGI ID: MGI:3040376
• Transgene: Tg(MMTVTGFB1)46Hlm Location: unknown
• Alliance: Tg(MMTVTGFB1)46Hlm page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the mouse mammary tumor virus promoter and a modified allele of simian transforming growth factor, beta 1. In this modified allele cystein codons at positions 223 and 225 were changed to serine codons (this generates an active form of TGFB1). The construct also contained exons 2 and 3 of the rabbit beta-globin gene. (J:72128)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTVTGFB1)46Hlm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:72128 Pierce DF Jr, et al., Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1. Genes Dev. 1993 Dec;7(12A):2308-17
• All: 4 reference(s)