Setdb1^tm1Enl
Targeted Allele Detail

Summary

• Symbol: Setdb1^tm1Enl
• Name: SET domain, bifurcated 1; targeted mutation 1, En Li
• MGI ID: MGI:3040431
• Synonyms: Eset^-
• Gene: Setdb1 Location: Chr3:95230836-95264513 bp, - strand Genetic Position: Chr3, 40.74 cM, cytoband F2
• Alliance: Setdb1^tm1Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89058
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 15-22 were replaced with an IRES-betageo cassette. These exons encode the pre- and post-SET catalytic region of the protein, and removal was predicted to abolish all activity. X-gal staining detected lacZ expression in homozygous embryos. (J:89058)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setdb1 Mutation: 56 strains or lines available

References

• Original: J:89058 Dodge JE, et al., Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol. 2004 Mar;24(6):2478-86
• All: 1 reference(s)