Ghsr^tm1Rgs
Targeted Allele Detail

Summary

• Symbol: Ghsr^tm1Rgs
• Name: growth hormone secretagogue receptor; targeted mutation 1, Roy G Smith
• MGI ID: MGI:3040440
• Synonyms: Ghsr^-, GHSR KO
• Gene: Ghsr Location: Chr3:27425500-27432159 bp, + strand Genetic Position: Chr3, 10.86 cM
• Alliance: Ghsr^tm1Rgs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89243
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of exon 1 and part of the coding region of exon 2 were replaced with a pGKneo cassette via homologous recombination. RT-PCR demonstrated lack of mRNA in homozygous mutant pituitary glands. (J:89243)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghsr Mutation: 27 strains or lines available

References

• Original: J:89243 Sun Y, et al., Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4679-84
• All: 45 reference(s)