Tg(CTSG-PML/RARA)#Ppp
Transgene Detail

Summary

• Symbol: Tg(CTSG-PML/RARA)#Ppp
• Name: transgene insertion, Pier Paolo Pandolfi
• MGI ID: MGI:3040508
• Synonyms: hCG-PML-RARalpha TG
• Transgene: Tg(CTSG-PML/RARA)#Ppp Location: unknown
• Alliance: Tg(CTSG-PML/RARA)#Ppp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene expresses a fusion protein: the N-terminal 530 amino acids of PML fused to the C-terminal 402 amino acids of RARA. Transgene expression is driven by the human cathepsin G (CTSG) promoter. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:40373)

Tumor Data

List all tumor models in MMHCdb carrying Tg(CTSG-PML/RARA)#Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic mice were derived from two founder lines (No. 6179 and 6380). The test population in the original study was composed of offspring from both founders.

References

• Original: J:40373 He LZ, et al., Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5302-7
• All: 7 reference(s)