Dct^Slt-lt3J
Spontaneous Allele Detail

Summary

• Symbol: Dct^Slt-lt3J
• Name: dopachrome tautomerase; slaty light 3 Jackson
• MGI ID: MGI:3040516
• Synonyms: nm2798
• Gene: Dct Location: Chr14:118250202-118289656 bp, - strand Genetic Position: Chr14, 61.6 cM
• Alliance: Dct^Slt-lt3J page

Mutation origin

• Strain of Origin: B6.Cg-Lep^ob/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A single base pair mutation of G-to-A resulted in an amino acid substitution of glycine with arginine at position 486 (p.G486R) within the transmembrane domain encoded by exon 8. (J:141035)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dct Mutation: 35 strains or lines available

References

• Original: J:141035 Anderson MG, et al., Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res. 2008 Oct;21(5):565-78
• All: 1 reference(s)