Nkx2-5^tm2Siz
Targeted Allele Detail

Summary

• Symbol: Nkx2-5^tm2Siz
• Name: NK2 homeobox 5; targeted mutation 2, Seigo Izumo
• MGI ID: MGI:3040604
• Synonyms: Nkx2-5^neo
• Gene: Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
• Alliance: Nkx2-5^tm2Siz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89216
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 1 and an additional loxP site was inserted 3' of exon 2. Northern blot indicated a 50% reduction of mRNA in mutant adult ventricular myocardium. (J:89216)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-5 Mutation: 21 strains or lines available

References

• Original: J:89216 Jay PY, et al., Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest. 2004 Apr;113(8):1130-7
• All: 2 reference(s)