Tg(Mt1-Tgfa)149Bri
Transgene Detail

Summary

• Symbol: Tg(Mt1-Tgfa)149Bri
• Name: transgene insertion 149, Ralph L Brinster
• MGI ID: MGI:3040606
• Synonyms: 1745-8, MT-TGF-alpha-mini 1745-8, MT-TGFalpha-mini Line 1745-8, MT-TGFa-mini, Tg(Mt-1,rTGFa)Bri149, Tg(Mt-I, Tgf-alpha)Bril4c
• Transgene: Tg(Mt1-Tgfa)149Bri Location: unknown
• Alliance: Tg(Mt1-Tgfa)149Bri page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-Tgfa)149Bri expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Tgfa (24827)

  Tgfa	(MGI:98724)

• Mutation details: This transgene contains the mouse metallothionein 1 promoter and rat transforming growth factor alpha cDNA. The vector also contains a small part of the human growth hormone gene (containing poly(A)). The construct was designated "MT-TGFalpha-mini", "Line 1745-8". (J:28451)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Mt1-Tgfa)149Bri

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Mice on a mixed C57BL/6 x SJL background that carry this transgene are also called "MT-TGFalpha-mini Line 1745-8."

References

• Original: J:28451 Sandgren EP, et al., Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell. 1990 Jun 15;61(6):1121-35
• All: 12 reference(s)