Dnaja3^tm1.1Jdl
Targeted Allele Detail

Summary

• Symbol: Dnaja3^tm1.1Jdl
• Name: DnaJ heat shock protein family (Hsp40) member A3; targeted mutation 1.1, Jiing-Dwan Lee
• MGI ID: MGI:3040717
• Synonyms: Tid1^f
• Gene: Dnaja3 Location: Chr16:4501934-4525559 bp, + strand Genetic Position: Chr16, 2.46 cM
• Alliance: Dnaja3^tm1.1Jdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89091
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Flp-mediated recombination removed the frt-flanked neo cassette in Dnaja3^tm1Jdl, leaving floxed exon 2. Western blot of mutant MEFs demonstrated protein expression was that of wild-type. (J:89091)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnaja3 Mutation: 43 strains or lines available

References

• Original: J:89091 Lo JF, et al., Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival. Mol Cell Biol. 2004 Mar;24(6):2226-36
• All: 4 reference(s)