Ccnf^tm1.1Sje
Targeted Allele Detail

Summary

• Symbol: Ccnf^tm1.1Sje
• Name: cyclin F; targeted mutation 1.1, Stephen J Elledge
• MGI ID: MGI:3040863
• Synonyms: Cycf^-
• Gene: Ccnf Location: Chr17:24441518-24470333 bp, - strand Genetic Position: Chr17, 12.32 cM
• Alliance: Ccnf^tm1.1Sje page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89060
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Floxed exon 2 and neo cassette are removed following transient Cre-mediated recombination, leaving a single loxP site. Removal of exon 2 putatively generates a null mutation by preventing the encoding of F box as well as the creation of a frameshift mutation and a premature stop codon after encoding 5 amino acids and 39 amino acids, respectively. PCR confirmed recombination. (J:89060)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnf Mutation: 51 strains or lines available

References

• Original: J:89060 Tetzlaff MT, et al., Cyclin F disruption compromises placental development and affects normal cell cycle execution. Mol Cell Biol. 2004 Mar;24(6):2487-98
• All: 1 reference(s)