Ahnak^tm1Vtm
Targeted Allele Detail

Summary

• Symbol: Ahnak^tm1Vtm
• Name: AHNAK nucleoprotein; targeted mutation 1, Vincent T Marchesi
• MGI ID: MGI:3040870
• Synonyms: Ahnak^-, Ahnak1^-
• Gene: Ahnak Location: Chr19:8966648-9054278 bp, + strand Genetic Position: Chr19, 6.04 cM, cytoband A
• Alliance: Ahnak^tm1Vtm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89231
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced 5.3 kb of sequence encompassing the putative promoter, 5' UTR, and a segment of the coding region. Northern blot of mutant heart ventricles indicated no transcript was present, and absence of normal protein was confirmed by immunoblot. (J:89231)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ahnak Mutation: 317 strains or lines available

References

• Original: J:89231 Komuro A, et al., The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells. Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4053-8
• All: 3 reference(s)