Per2^tm1Jt
Targeted Allele Detail

Summary

• Symbol: Per2^tm1Jt
• Name: period circadian clock 2; targeted mutation 1, Joseph S Takahashi
• MGI ID: MGI:3040876
• Synonyms: mPer2^Luc, mPER2::LUC, mPer2^Luciferase, mPer2::Luc^ki, Per2^Luc
• Gene: Per2 Location: Chr1:91343699-91387028 bp, - strand Genetic Position: Chr1, 46.13 cM, cytoband C5
• Alliance: Per2^tm1Jt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89256
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A luciferase gene and floxed neo cassette were inserted between exon 23 and the 3' UTR. Mutant transcript was detected in Northern blot of mutant brains and the Per2-Luc fusion protein was detected in Western blots of mutant kidneys. (J:89256)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Per2 Mutation: 73 strains or lines available

References

• Original: J:89256 Yoo SH, et al., PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5339-46
• All: 254 reference(s)