Tg(MtTGFA)100Lmb
Transgene Detail

Summary

• Symbol: Tg(MtTGFA)100Lmb
• Name: transgene insertion 100, Glenn Merlino
• MGI ID: MGI:3040889
• Transgene: Tg(MtTGFA)100Lmb Location: unknown
• Alliance: Tg(MtTGFA)100Lmb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MtTGFA)100Lmb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFA (7039)

  Tgfa	(MGI:98724)

• Mutation details: This transgene contains the inducible mouse metallothionein 1 promoter, cDNA of the wild-type allele of the human transforming growth factor alpha gene, and a human growth hormone polyadenylation signal. Line 100 carries ten copies of the transgene. (J:28452)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MtTGFA)100Lmb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:28452 Jhappan C, et al., TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell. 1990 Jun 15;61(6):1137-46
• All: 9 reference(s)