Zfp148^tm1Kii
Targeted Allele Detail

Summary

• Symbol: Zfp148^tm1Kii
• Name: zinc finger protein 148; targeted mutation 1, Ken-ichi Isobe
• MGI ID: MGI:3040891
• Gene: Zfp148 Location: Chr16:33201145-33324273 bp, + strand Genetic Position: Chr16, 23.93 cM
• Alliance: Zfp148^tm1Kii page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:81445
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 9, which makes up over 60% of the coding region, was replaced with a neo cassette via homologous recombination. Northern blot analysis showed decreased expression in heterozygous stem cells. (J:81445)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp148 Mutation: 112 strains or lines available

Notes

Haploinsufficiency of Zfp148 prevents genetic transmission of the mutated allele and generation of non-chimeric heterozygous mice. All phenotype data reported are from chimeric mice.

References

• Original: J:81445 Takeuchi A, et al., Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Nat Genet. 2003 Feb;33(2):172-6
• All: 1 reference(s)