Chrna5^tm1Mdb
Targeted Allele Detail

Summary

• Symbol: Chrna5^tm1Mdb
• Name: cholinergic receptor, nicotinic, alpha polypeptide 5; targeted mutation 1, Mariella De Biasi
• MGI ID: MGI:3040917
• Synonyms: Alpha5^-
• Gene: Chrna5 Location: Chr9:54888164-54915063 bp, + strand Genetic Position: Chr9, 29.84 cM
• Alliance: Chrna5^tm1Mdb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89620
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5, encoding three transmembrane regions and the long intracellular loop, was replaced with a neo cassette. Northern blot confirmed absence of mRNA in mutant brains. (J:89620)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Chrna5 Mutation: 39 strains or lines available

References

• Original: J:89620 Salas R, et al., The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivo. Mol Pharmacol. 2003 May;63(5):1059-66
• All: 40 reference(s)