Angpt2^tm1Gdy
Targeted Allele Detail

Summary

• Symbol: Angpt2^tm1Gdy
• Name: angiopoietin 2; targeted mutation 1, George D Yancopoulos
• MGI ID: MGI:3040929
• Synonyms: Ang-2^-, Ang2^-, Ang-2/LacZ, Ang2^LZ, Angpt2-
• Gene: Angpt2 Location: Chr8:18740279-18791578 bp, - strand Genetic Position: Chr8, 10.3 cM
• Alliance: Angpt2^tm1Gdy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89618
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and neo cassette was inserted into the first exon, deleting 310 bp of exon 1, spanning the translation initiation site and the first 257 bp (85 codons). Lack of transcript was confirmed by Northern blot of mutant heart, kidney and lung. Beta-galactosidase was expressed from this allele under the control of the endogenous promoter. (J:89618)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angpt2 Mutation: 46 strains or lines available

References

• Original: J:89618 Gale NW, et al., Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell. 2002 Sep;3(3):411-23
• All: 22 reference(s)