Angpt2^{tm2(Angpt1)Gdy}
Targeted Allele Detail

Summary

• Symbol: Angpt2^{tm2(Angpt1)Gdy}
• Name: angiopoietin 2; targeted mutation 2, George D Yancopoulos
• MGI ID: MGI:3040930
• Synonyms: Ang2^A1
• Gene: Angpt2 Location: Chr8:18740279-18791578 bp, - strand Genetic Position: Chr8, 10.3 cM
• Alliance: Angpt2^{tm2(Angpt1)Gdy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89618
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Angpt2^{tm2(Angpt1)Gdy} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Angpt1 (MGI:108448)

• Mutation details: Angpt1 coding sequence was inserted into exon 1. RT-PCR revealed presence of Angpt1 transcript, but not that of Angpt2 in mutants. (J:89618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angpt2 Mutation: 46 strains or lines available

References

• Original: J:89618 Gale NW, et al., Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell. 2002 Sep;3(3):411-23
• All: 3 reference(s)