Tfap2c^tm1.1Hsc
Targeted Allele Detail

Summary

• Symbol: Tfap2c^tm1.1Hsc
• Name: transcription factor AP-2, gamma; targeted mutation 1.1, Hubert Schorle
• MGI ID: MGI:3040993
• Gene: Tfap2c Location: Chr2:172391513-172400542 bp, + strand Genetic Position: Chr2, 94.87 cM, cytoband H3-H4
• Alliance: Tfap2c^tm1.1Hsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78934
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A single loxP site was inserted 5' to exon 5 and a loxP flanked neomycin and thymidine kinase selection cassette was inserted 3' to exon 5. Exon 5 and the neomycin and thymidine kinase selection cassette were removed in ES cells by Cre mediated recombination prior to the production of chimeric mice, resulting in the null allele. (J:78934)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap2c Mutation: 28 strains or lines available

References

• Original: J:78934 Werling U, et al., Transcription factor gene AP-2 gamma essential for early murine development. Mol Cell Biol. 2002 May;22(9):3149-56
• All: 4 reference(s)