Met^tm1Sst
Targeted Allele Detail

Summary

• Symbol: Met^tm1Sst
• Name: met proto-oncogene; targeted mutation 1, Snorri S Thorgeirsson
• MGI ID: MGI:3041135
• Synonyms: c-met^fl, cMet^lox, Met^flx, Met^lox
• Gene: Met Location: Chr6:17463799-17573979 bp, + strand Genetic Position: Chr6, 7.83 cM, cytoband A2
• Alliance: Met^tm1Sst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89236
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 16 was left flanked by single loxP sites following cre-mediated excision of floxed neo cassette from intron 16. (J:89236)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Met Mutation: 83 strains or lines available

References

• Original: J:89236 Huh CG, et al., Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A. 2004 Apr 30;101(13):4477-82
• All: 63 reference(s)