Del(8Col4a1-Col4a2)1Epo
Targeted Allele Detail

Summary

• Symbol: Del(8Col4a1-Col4a2)1Epo
• Name: deletion, Chr8, Ernst Poschl 1; deletion, Chr 8, Ernst Poschl 1
• MGI ID: MGI:3041149
• Synonyms: Col4a1/Col4a2^tm1Epo
• Gene: Del(8Col4a1-Col4a2)1Epo Location: unknown Genetic Position: Chr8, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89190
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(8Col4a1-Col4a2)1Epo involves 2 genes/genome features (Col4a1, Col4a2) View all
• Mutation details: Exon 1 of Col4a1 and exons 1-3 of Col4a2 were replaced with a neo cassette. RT-PCR indicated lack of mRNA for both genes in homozygous mutant mice embryos. (J:89190)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(8Col4a1-Col4a2)1Epo Mutation: 0 strains or lines available

References

• Original: J:89190 Poschl E, et al., Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development. 2004 Apr;131(7):1619-28
• All: 3 reference(s)