Bpq8^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Bpq8^C3H/HeJ
• Name: blood pressure QTL 8; C3H/HeJ
• MGI ID: MGI:3041271
• QTL: Bpq8 Location: Chr1:160284665-160284803 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 69.75 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:89267

Linkage analysis was performed on 217 (C3H/HeJ x SWR/J)F2 intercross animals to identify QTLs associated with blood pressure. Parental strain SWR/J is hypertensive compared to parental strain C3H/HeJ. Genome scan was conducted using 103 polymorphic markers.

Bpq8 (blood pressure QTL 8) mapped to 78 cM on mouse Chromosome 1 with LOD=3.5 at D1Mit105. This locus explains 4.5% of the phenotypic variance. The QTL range of Bpq8 is broad spanning 64 cM - 106 cM. SWR/J-derived alleles confer increased blood pressure with dominant inheritance at this locus. Bpq8 overlaps with a previously identified blood pressure QTL named Bpq2 (81.6 cM). The QTL interval was narrowed significantly by combining data from the Bpq8 and Bpq2 crosses. Combining data narrowed the Bpq8 QTL range to 68 cM -86 cM and increased the LOD score to 6.38. Haplotype analysis comparing the allelic differences between hypertensive strains (C57BL/6J, SWR/J) and normotensive strains (A/J, C3H/HeJ) further reduced the Bpq8 interval to a 2.3 cM region centered around 81.6 cM.

Bpq9 mapped to 56 cM on mouse Chromosome 16 with LOD=3.6 at D16Mit159. This locus explains 5.9% of the phenotypic variance. The QTL range of Bpq9 spans 46 cM - 58 cM. Interestingly, homozygosity for SWR/J-derived alleles or homozygosity for C3H/HeJ-derived alleles confer increased blood pressure compared to heterozygotes. Further analysis gave evidence of two separate but closely linked QTLs at 44 cM and 54 cM with opposite allele effects.

References

• Original: J:89267 DiPetrillo K, et al., Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice. Physiol Genomics. 2004 Apr 13;17(2):215-20
• All: 1 reference(s)