Pparg^tm1.1Mtz
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1.1Mtz
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Daniel Metzger
• MGI ID: MGI:3041450
• Synonyms: PPARgammaL^-, Pparg^delta
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1.1Mtz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89238
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Pparg^tm1Mtz excised the sequence between the most 5' and 3' LoxP sites, removing exons 1 and 2 and the floxed neo. Exon 1 contains the initiator methionine codon for the gamma 1 isoform and exon 2 encodes the first zinc finger of the DNA-binding domain for gamma 1 and gamma 2 isoforms. PCR confirmed recombination. (J:89238)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Pparg^tm1.1Mtz/Pparg^tm1.1Mtz	involves: C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
embryo	√
abnormal placenta development	√
mortality/aging	√
embryonic lethality during organogenesis, complete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 42 strains or lines available

References

• Original: J:89238 Imai T, et al., Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A. 2004 Apr 30;101(13):4543-7
• All: 7 reference(s)