Nr1h2^tm1Djm
Targeted Allele Detail

Summary

• Symbol: Nr1h2^tm1Djm
• Name: nuclear receptor subfamily 1, group H, member 2; targeted mutation 1, David J Mangelsdorf
• MGI ID: MGI:3041856
• Synonyms: LXRbeta^-
• Gene: Nr1h2 Location: Chr7:44199040-44203375 bp, - strand Genetic Position: Chr7, 28.83 cM
• Alliance: Nr1h2^tm1Djm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64343
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a targeting vector replaced exons 5 and 6 with a neomycin resistance cassette creating a null allele. Exons 5 and 6 encode the DNA-binding and ligand-binding domains.

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Nr1h2 Mutation: 26 strains or lines available

References

• Original: J:64343 Repa JJ, et al., Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers [see comments]. Science. 2000 Sep 1;289(5484):1524-9
• All: 93 reference(s)