Tg(Col1a1-cre)1Kry
Transgene Detail

Summary

• Symbol: Tg(Col1a1-cre)1Kry
• Name: transgene insertion 1, Gerard Karsenty
• MGI ID: MGI:3041864
• Synonyms: 2.3kb alpha1(I)-cre, alpha1(1) collagen-Cre, alpha1(I)collagen-Cre, alpha1(I)-Cre, Col1a12.3kbCre, Col1-Cre, Col2.3-Cre, Col-Cre
• Transgene: Tg(Col1a1-cre)1Kry Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Tg(Col1a1-cre)1Kry page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Col1a1-cre)1Kry expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Col1a1

• Mutation details: Sequence encoding cre recombinase was adjoined to 2.3 kb of the Col1a1 promoter. The endogenous Col1a1 promoter is active in osteoblasts throughout their differentiation and, accordingly, expression of cre recombinase was detected exclusively in bone. Cytogenetic mapping indicates that the transgene integrated on chromosome 14qE2-4. (J:77071, J:165282)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col1a1 (species not specified) Summary of all recombinase alleles driven by Col1a1. Comparative matrix view of recombinase activities

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:77071 Dacquin R, et al., Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast. Dev Dyn. 2002 Jun;224(2):245-51
• All: 149 reference(s)