Mapk3^tm1Gela
Targeted Allele Detail

Summary

• Symbol: Mapk3^tm1Gela
• Name: mitogen-activated protein kinase 3; targeted mutation 1, Gary E Landreth
• MGI ID: MGI:3042006
• Synonyms: ERK1 -, Mapk3^tm1Jsw, Mapk3^tm1Tgf
• Gene: Mapk3 Location: Chr7:126358798-126364988 bp, + strand Genetic Position: Chr7, 69.25 cM
• Alliance: Mapk3^tm1Gela page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77455
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Mutation details: A targeting construct was designed to replace exons 1-6 of the protein coding sequence, including protein kinase domains I-X, with a neomycin resistance gene flanked by loxP sites. The null allele was confirmed by Western blot analysis. (J:77455, J:107504)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Mapk3^tm1Gela

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk3 Mutation: 26 strains or lines available

References

• Original: J:77455 Selcher JC, et al., Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning. Learn Mem. 2001 Jan-Feb;8(1):11-9
• All: 40 reference(s)