Arnt^tm1Bra
Targeted Allele Detail

Summary

• Symbol: Arnt^tm1Bra
• Name: aryl hydrocarbon receptor nuclear translocator; targeted mutation 1, Christopher A Bradfield
• MGI ID: MGI:3042111
• Synonyms: Arnt 3-lox, Arnt^3lox
• Gene: Arnt Location: Chr3:95341699-95404551 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Arnt^tm1Bra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89470
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A global hypomorphic Arnt allele was generated by inserting a neo cassette flanked by Loxp sites 3' of exon 6, which encodes the basic helix-loop-helix domain. A third loxp site was inserted 5' of exon 6. Western blot analysis confirmed decreased Arnt expression in all tissues examined from homozygous mice. (J:89470)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arnt Mutation: 65 strains or lines available

References

• Original: J:89470 Walisser JA, et al., Patent ductus venosus and dioxin resistance in mice harboring a hypomorphic Arnt allele. J Biol Chem. 2004 Apr 16;279(16):16326-31
• All: 8 reference(s)