Pdc^tm1Vya
Targeted Allele Detail

Summary

• Symbol: Pdc^tm1Vya
• Name: phosducin; targeted mutation 1, Vadim Y Arshavsky
• MGI ID: MGI:3042204
• Synonyms: Pd^-
• Gene: Pdc Location: Chr1:150195168-150209657 bp, + strand Genetic Position: Chr1, 63.84 cM
• Alliance: Pdc^tm1Vya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89499
• Parent Cell Line: IT2 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter region and exon 1 were replaced with a neo cassette via homologous recombination. Western blot analysis showed the absence of protein in homozygous null mice. (J:89499)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdc Mutation: 22 strains or lines available

References

• Original: J:89499 Sokolov M, et al., Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse. J Biol Chem. 2004 Apr 30;279(18):19149-56
• All: 4 reference(s)