Pla2g5^tm1Jarm
Targeted Allele Detail

Summary

• Symbol: Pla2g5^tm1Jarm
• Name: phospholipase A2, group V; targeted mutation 1, Jonathan P Arm
• MGI ID: MGI:3042209
• Synonyms: Group V sPLA2-null
• Gene: Pla2g5 Location: Chr4:138526558-138590784 bp, - strand Genetic Position: Chr4, 70.57 cM
• Alliance: Pla2g5^tm1Jarm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89490
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was deleted and replaced with a neo cassette lacking a poladenylation signal via homologous recombination. Only abnormal short transcripts were detected by northern blotting and RT-PCR in homozygous mice. Immunofluorescence confirmed the absence of protein expression. (J:89490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g5 Mutation: 23 strains or lines available

References

• Original: J:89490 Satake Y, et al., Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. J Biol Chem. 2004 Apr 16;279(16):16488-94
• All: 23 reference(s)