Amhr2^tm3(cre)Bhr
Targeted Allele Detail

Summary

• Symbol: Amhr2^tm3(cre)Bhr
• Name: anti-Mullerian hormone type 2 receptor; targeted mutation 3, Richard R Behringer
• MGI ID: MGI:3042214
• Synonyms: Amh-mis-Cre, Amhr2-cre, Amhr2^cre, Amhr-2/Cre, Amhr2cre, Amhr2-IRES-Cre(Bhr)
• Gene: Amhr2 Location: Chr15:102353802-102363068 bp, + strand Genetic Position: Chr15, 57.58 cM
• Alliance: Amhr2^tm3(cre)Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89999
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Amhr2^tm3(cre)Bhr expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Amhr2 (MGI:105062)

• Mutation details: A cassette containing IRES-cre and an FRT-flanked neo cassette was inserted into exon 5 of the endogenous gene. Expression of functional cre recombinase was detected in both male and female gonads and in the Mullerian duct. Based on phenotypic similarity to previously described Amhr2 deficient mice, this allele is putatively null. (J:89999, J:118270)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Amhr2 (mouse) Summary of all recombinase alleles driven by Amhr2. Comparative matrix view of recombinase activities Alliance mouse Amhr2 gene page

Disease models

Expression

In Mice Carrying this Mutation:	187 assay results 8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Amhr2^tm3(cre)Bhr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Amhr2 Mutation: 29 strains or lines available

References

• Original: J:89999 Jamin SP, et al., Requirement of Bmpr1a for Mullerian duct regression during male sexual development. Nat Genet. 2002 Nov;32(3):408-10
• All: 170 reference(s)