Hand1^tm1Cse
Targeted Allele Detail

Summary

• Symbol: Hand1^tm1Cse
• Name: heart and neural crest derivatives expressed 1; targeted mutation 1, Peter Cserjesi
• MGI ID: MGI:3042297
• Synonyms: Hand1^B-gal, hand1lacZ
• Gene: Hand1 Location: Chr11:57719539-57722973 bp, - strand Genetic Position: Chr11, 35.27 cM
• Alliance: Hand1^tm1Cse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89474
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 174 amino acids of exon 1 were replaced with in-frame beta-galactosidase and a neo cassette via homologous recombination. Beta-galactosidase expression recapitulates endogenous protein expression. (J:89474)

Expression

In Mice Carrying this Mutation:

14 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand1 Mutation: 15 strains or lines available

References

• Original: J:89474 Morikawa Y, et al., Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Development. 2004 May;131(9):2195-204
• All: 5 reference(s)