Doc2a^tm1Ytk
Targeted Allele Detail

Summary

• Symbol: Doc2a^tm1Ytk
• Name: double C2, alpha; targeted mutation 1, Yoshimi Takai
• MGI ID: MGI:3042481
• Synonyms: Doc2alpha^-
• Gene: Doc2a Location: Chr7:126446588-126451877 bp, + strand Genetic Position: Chr7, 69.25 cM, cytoband F4
• Alliance: Doc2a^tm1Ytk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89423
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region spanning the start codon to exon 3 was replaced by LacZ and neo cassettes. Western blot confirmed lack of protein in mutants. (J:89423)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Doc2a Mutation: 15 strains or lines available

References

• Original: J:89423 Sakaguchi G, et al., Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission. Eur J Neurosci. 1999 Dec;11(12):4262-8
• All: 12 reference(s)