Icam5^tm1(cre)Mmsh
Targeted Allele Detail

Summary

• Symbol: Icam5^tm1(cre)Mmsh
• Name: intercellular adhesion molecule 5, telencephalin; targeted mutation 1, Masayoshi Mishina
• MGI ID: MGI:3042494
• Synonyms: TLCN-Cre
• Gene: Icam5 Location: Chr9:20943372-20950331 bp, + strand Genetic Position: Chr9, 7.7 cM, cytoband A3
• Alliance: Icam5^tm1(cre)Mmsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89407
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Icam5^tm1(cre)Mmsh expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Icam5 (MGI:109430)

• Mutation details: Cre recombinase and neomycin resistance genes replaced an 82 bp exonic sequence encoding the start codon and the following 69 bp of intronic sequence. In situ hybridization demonstrated the absence of normal RNA and Western blot confirmed absence of normal protein from mutant mice. (J:89407)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Icam5 (mouse) Summary of all recombinase alleles driven by Icam5. Alliance mouse Icam5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icam5 Mutation: 28 strains or lines available

References

• Original: J:89407 Nakamura K, et al., Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. Eur J Neurosci. 2001 Jan;13(1):179-89
• All: 36 reference(s)