Nkx2-5^tm1Krc
Targeted Allele Detail

Summary

• Symbol: Nkx2-5^tm1Krc
• Name: NK2 homeobox 5; targeted mutation 1, Kenneth R Chien
• MGI ID: MGI:3042511
• Synonyms: Nkx2-5^fl
• Gene: Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
• Alliance: Nkx2-5^tm1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89404
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to span exon 2, which contains the homeobox domain. Southern blot confirmed successful homologous recombination. (J:89404)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-5 Mutation: 21 strains or lines available

References

• Original: J:89404 Pashmforoush M, et al., Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 2004 Apr 30;117(3):373-86
• All: 13 reference(s)