Bace1^tm1Bux
Targeted Allele Detail

Summary

• Symbol: Bace1^tm1Bux
• Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Joseph D Buxbaum
• MGI ID: MGI:3042562
• Gene: Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
• Alliance: Bace1^tm1Bux page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89370
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first exon was replaced with an IRES-beta-galactosidase expression cassette and a MC1-neomycin resistance gene. Western blot analysis of brain extracts confirmed the absence of protein product. Beta-galactosidase activity driven by the Bace1 promoter was detected. (J:89370)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bace1 Mutation: 30 strains or lines available

References

• Original: J:89370 Pastorino L, et al., BACE (beta-secretase) modulates the processing of APLP2 in vivo. Mol Cell Neurosci. 2004 Apr;25(4):642-9
• All: 2 reference(s)