Kcna3^tm1Gvd
Targeted Allele Detail

Summary

• Symbol: Kcna3^tm1Gvd
• Name: potassium voltage-gated channel, shaker-related subfamily, member 3; targeted mutation 1, Gary V Desir
• MGI ID: MGI:3042596
• Synonyms: Kv1.3^-
• Gene: Kcna3 Location: Chr3:106943485-106945386 bp, + strand Genetic Position: Chr3, 46.59 cM
• Alliance: Kcna3^tm1Gvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89447
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced the promoter region and the 5' third of the coding region. Western blot detected no wild-type protein in mutants. (J:89447)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcna3 Mutation: 22 strains or lines available

References

• Original: J:89447 Xu J, et al., The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Hum Mol Genet. 2003 Mar 1;12(5):551-9
• All: 7 reference(s)